Amisulpride: tackling postoperative nausea and vomiting not a nightmare any more

Postoperative nausea and vomiting

Postoperative nausea and vomiting (PONV) is a long-standing issue, not a new concept in anesthesiology. Despite many studies over the last several decades, PONV remains a significant problem due to its complex mechanism. This review presents a summary of the mechanism underlying the pathogenesis of PONV, focusing on preventive treatment, particularly the use of new drugs. In addition, we discus...

Postoperative Nausea and Vomiting

I.V. APD421 (amisulpride) prevents postoperative nausea and vomiting: a randomized, double-blind, placebo-controlled, multicentre trial.

BACKGROUND Postoperative nausea and vomiting (PONV) remain significant clinical problems for patients, especially nausea. The D2-antagonist droperidol was popular for prophylaxis until safety concerns limited its use. In early testing, APD421 (amisulpride for i.v. injection), a D2/D3-antagonist, has shown promising antiemetic efficacy at very low doses. We conducted a randomized, double-blind, ...

Controlling postoperative nausea and vomiting

Postoperative nausea and vomiting (PNV) in the ambulatory surgical unit is a continuing and vexing problem. Delayed discharges and patient discomfort have major impact in an outpatient setting. An understanding of the causes and aetiologies of PNV including anaesthetic, surgical and patient factors is critically important in the management of these patients. Therapy begins with a good history, ...

Postoperative nausea and vomiting--a review.

Post operative nausea and vomiting (PONV) remains an unpleasant and persistent problem for patients undergoing surgery. In fact PONV are among the most important factors contributing to delay in discharge of patients and an increase in unanticipated admissions after ambulatory surgery. Anesthesia providers are most often blamed for PONV, sometimes rightfully so, many times wrongly so. PONV is a...